Recommendations for Clinical CYP2C19 Genotyping Allele Selection

Enroll

  • This content was reviewed no later than 3 years post-recording; CPC determined it was still useful and relevant; an update was recommended. 
  • Revised and/or updated educational content is anticipated with the release of the associated guideline / manuscript update.
  • Content is scheduled for review at 6 years post-recording.

Please note that in the time since this material was published, there may have been additional developments, advancements, and/or more current publications in this field. Please contact AMPClinicalPractice@amp.org with questions or concerns.

Description: 

In this webinar, Dr. Karen Weck will present the recommendations of The AMP Pharmacogenomics Working Group of the Clinical Practice Committee for inclusion of variants in CYP2C19 genotyping panels. The working group has published consensus, evidence-based recommendations using criteria such as allele function, population frequency, and availability of reference materials. The recommendations include a Tier 1 minimum set of alleles and defining variants that should be included in all clinical CYP2C19 PGx tests, and a Tier 2 list of additional optional alleles that do not currently meet all of the criteria for inclusion in Tier 1. These recommendations are intended to aid clinical laboratory professionals when designing and validating CYP2C19 genotyping assays, promote standardization of testing across different laboratories, and complement existing clinical guidelines for pharmacogenetic testing.

Learning Objectives:

  • List the three most common alleles associated with CYP2C19 altered metabolism and their respective effects on enzymatic function.
  • Give examples of key drugs in clinical use that are affected by CYP2C19 genetic variability affecting enzymatic activity.
  • Describe the key characteristics of pharmacogenetic alleles that are recommended for inclusion in clinical testing platforms by the AMP PGx working group.

Practice Guideline Available Here

Speaker: Karen E. Weck, MD
Moderator: Joshua Deignan, PhD
Duration: 1 hr
Level of Instruction: Basic
Date Recorded: March 21, 2018

Continuing Education Credit Information

CE Credit for this course has expired.

Note: Join the AMP Family for discounted access to the most current educational resources!

All sales are final. No refunds will be issued.

No digital files may be reproduced or transmitted in any form, by any means, electronic or mechanical. By purchasing a product, you agree to not share any of the course materials, including videos, downloadable slide presentations, outlines, manuscripts, etc. without explicit and written permission from AMP.


Enroll