Recommendations for Cell-Free DNA Assay Validations



 Recommendations for Cell-Free DNA Assay Validations: A Joint Consensus Recommendation of the Association for Molecular Pathology and College of American Pathologists 


This course contains the webinar, a handout, and continuing education credit (CME and CMLE) 


This webinar is based on new best practice recommendations from the Association for Molecular Pathology for validating and reporting clinical circulating tumor DNA (ctDNA) or liquid biopsy assays and their related scientific publications. The AMP Liquid Biopsy Working Group, including organizational representation from the American Society of Clinical Oncology (ASCO) and College of American Pathologists (CAP), reviewed more than 1,200 publications that describe ctDNA assay performance in patients with lymphoma and solid tumor malignancies. The recommendations, which are based on the AMP Liquid Biopsy Working Group’s scoping review and subject matter expert professional experience, include reporting key pre-analytical considerations and assay performance metrics.


Learning Objectives:

  • Identify current challenges in ctDNA assay performance and reporting, including pre-analytical variables, analytical considerations, and elements of laboratory assay reporting.
  • Discuss new consensus recommendations that are intended to assist clinical laboratories with validating and reporting ctDNA assays and to ensure high quality data is included in publications.


Christina M. Lockwood, PhD
University of Washington



Anthony N. Snow, MD
University of Iowa Hospitals and Clinics


Duration: 1 Hour
Level of Instruction: 
Live Webinar: April 11, 2024
Date Recorded
February 27, 2024


Planned and coordinated by the Training and Education Committee

Continuing Education Credit Information

CME credit: 1.0
CMLE credit: 1.0 
Last day to claim credit:  March 20, 2026

Accreditation Statements
AMA PRA Category 1 Credit(s)
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint providership of American Society for Clinical Pathology (ASCP) and Association for Molecular Pathology (AMP). The American Society for Clinical Pathology (ASCP) is accredited by the ACCME to provide continuing medical education for physicians.

The ASCP designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

This continuing medical laboratory education activity is recognized by the American Society for Clinical Pathology for 1.0 hours of CMLE credit. ASCP CMLE credit hours are acceptable for the ASCP Board of Certification (BOC) Certification Maintenance Program (CMP). CMLE credit hours meet the continuing education requirements for the ASCP Board of Certification Credential Maintenance Program (CMP) and state relicensure requirements for laboratory personnel. Participants should claim only the credit commensurate with the extent of their participation in the activity. 

Note: Members of AMP can access this webinar at no cost. Join the AMP Family!


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No digital files may be reproduced or transmitted in any form, by any means, electronic or mechanical. By purchasing a product, you agree to not share any of the course materials, including videos, downloadable slide presentations, outlines, manuscripts, etc. without explicit and written permission from AMP.