Assessments of Somatic Variant Classification Using the AMP/ASCO/CAP Guidelines

 Assessments of Somatic Variant Classification Using the AMP/ASCO/CAP Guidelines

This contains the webinar and continuing education credit (CME and CMLE) 


This webinar is based on a new Report from the Association for Molecular Pathology, which assesses the clinical implementation of the 2017 AMP/ASCO/CAP “Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer” guideline. The AMP Variant Interpretation Across Testing Laboratories (VITAL) Somatic Working Group was formed to better understand the implementation and utilization of the guideline among laboratories, assess concordance between laboratories, and identify content within the guidelines that may result in variant classification inconsistencies between laboratories. The project involved VITAL Somatic Challenges and an implementation survey. Opportunities for improvement to drive the adoption of the AMP/ASCO/CAP somatic variant classification system are discussed.

Learning Objectives:

      • Discuss the VITAL Somatic Challenge findings regarding the utilization of the AMP/ASCO/CAP variant classification guideline.
      • Discuss the AMP/ASCO/CAP guideline utilization survey findings regarding clinical laboratory implementation of the guideline.
      • Identify opportunities to improve the tier-based variant classification system content, implementation, and adoption
      • Evaluate areas for potential updates within the AMP/ASCO/CAP variant classification guideline revision currently in development.


Marilyn M. Li, MD
Massachusetts General Hospital
Perelman School of Medicine 
at the University of Pennsylvania


Navid Sadri, MD, PhD
Case Western Reserve University School of Medicine
University Hospitals Cleveland Medical Center

Duration: 1 Hour
Level of Instruction: Intermediate
Date Recorded: January 19, 2023

Planned and coordinated by the Training and Education Committee

Continuing Education Credit Information

CME credit: 1.0
CMLE credit: 1.0 
Last day to claim credit:  March 20, 2025

Accreditation Statements
AMA PRA Category 1 Credit(s)
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint providership of American Society for Clinical Pathology (ASCP) and Association for Molecular Pathology (AMP). The American Society for Clinical Pathology (ASCP) is accredited by the ACCME to provide continuing medical education for physicians.

The ASCP designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

This continuing medical laboratory education activity is recognized by the American Society for Clinical Pathology for 1.0 hours of CMLE credit. ASCP CMLE credit hours are acceptable for the ASCP Board of Certification (BOC) Certification Maintenance Program (CMP). CMLE credit hours meet the continuing education requirements for the ASCP Board of Certification Credential Maintenance Program (CMP) and state relicensure requirements for laboratory personnel. Participants should claim only the credit commensurate with the extent of their participation in the activity. 

Note: Members of AMP can access this webinar at no cost. Join the AMP Family!

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