Utility of Clinical Metagenomic Next-Generation Sequencing for Diagnosis of Infections

Utility of Clinical Metagenomic Next-Generation Sequencing for Diagnosis of Infections

This webinar is a recorded presentation of a live broadcast and includes a pre-test, the presentation, handout, and a post-test. Continuing education credit is available for the webinar.

This interactive live webinar is part 7 of the 8 part Utility of Cell-Free DNA in the Clinic Series.


Metagenomic sequencing of body fluids from patients is a transformative approach to diagnose infections from nearly all pathogens, whether virus, bacterium, fungus, or parasite. 

This presentation will discuss emerging clinical applications of this technology, including detection of viral pathogens using a pocket-sized nanopore sequencer and the construction of RNA gene expression-based classifiers using machine learning algorithms to distinguish between infectious and non-infectious causes of acute illness

Learning Objectives:

  • Discuss the role of clinical metagenomic sequencing in diagnosis of unknown infections. 
  •  Identify the advantages and disadvantages of clinical metagenomic sequencing over other microbiological tests for pathogen detection
  • Summarize potential applications and clinical indications for this emerging diagnostic approach
  • Discuss new technological and bioinformatics advances in the metagenomic field (e.g. diagnostic and predictive classifiers based on the patient’s host response, nanopore sequencing)

    Charles Chiu, MD, PhD
    USCF School of Medicine
    Margaret Gulley, MD
    Duration: 1 Hour
    Level of Instruction: Basic

    Supported by an educational grant from AstraZeneca and by educational funding provided by Amgen.  

    Continuing Education Credit Information

    Recording Date: December 13, 2022
    CME credit: 1.0
    CMLE credit: 1.0 
    Last day to claim credit: December 31, 2023

    Physicians (ACCME)           

    In support of improving patient care, this activity has been planned and implemented by Amedco LLC and the Association for Molecular Pathology.  Amedco LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    Credit Designation Statement – Amedco LLC designates this live to enduring activity for a maximum of 8.00 AMA PRA Category 1 CreditsTM (1.00 CE for each webinar). Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

    Medical Laboratory Education (CMLE)

    This continuing medical laboratory education activity is recognized by the American Society for Clinical Pathology as meeting the criteria for up to 8 CMLE credits. ASCP CMLE credits are acceptable to meet the continuing education requirement for the ASCP Board of Registry Certification Maintenance Program.

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