Horizons Series: TPMT and NUDT15 Genotyping Recommendations

 TPMT and NUDT15 Genotyping Recommendations: A Joint Consensus 

This contains the webinar and continuing education credit (CME and CMLE) 


In this pre-recorded lecture, AMP Pharmacogenomics Working Group members Dr. Reynold Ly moderates as Dr. Makenzie Fulmer provides an update on clinical TPMT and NUDT15 testing, which was recently published online by the JMD. With a goal of promoting standardization of clinical PGx testing across different clinical laboratories, this Working Group has published recommendations on CYP2C19, CYP2C9, Warfarin allele and CYP2D6 genotyping allele selections previously, and now TPMT and NUDT15 selection for clinical laboratories to use as guidelines when designing and developing these PGx assays. Healthcare providers may also find these documents useful in comparing and contrasting PGx tests across clinical laboratories when they are familiar with a “must-test” list for each of the pharmacogenes.

Learning Objectives:
    • Review TPMT and NUDT15 pharmacogenetics (PGx) and highlight the importance of standardization of clinical PGx and its implications to patient care
    • Review the AMP PGx Working Group ‘Tier’ system of PGx sequence variants/alleles recommendation
    • Explain the key attributes of Tier 1 and Tier 2 recommended alleles for TPMT and NUDT15 genotyping

Makenzie L. Fulmer, PhD

Department of Pathology and ARUP Laboratories
University of Utah School of Medicine

Reynold C. Ly, PhD

Indiana University School of Medicine, 
Department of Medical and Molecular Genetics

Duration: 1 Hour
Level of Instruction: Intermediate
Date Recorded: August 30, 2022

Planned and coordinated by the Training and Education Committee

Continuing Education Credit Information

CME credit: 1.0
CMLE credit: 1.0 
Last day to claim credit:  March 20, 2025

Accreditation Statements
AMA PRA Category 1 Credit(s)
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint providership of American Society for Clinical Pathology (ASCP) and Association for Molecular Pathology (AMP). The American Society for Clinical Pathology (ASCP) is accredited by the ACCME to provide continuing medical education for physicians.

The ASCP designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

This continuing medical laboratory education activity is recognized by the American Society for Clinical Pathology for 1.0 hours of CMLE credit. ASCP CMLE credit hours are acceptable for the ASCP Board of Certification (BOC) Certification Maintenance Program (CMP). CMLE credit hours meet the continuing education requirements for the ASCP Board of Certification Credential Maintenance Program (CMP) and state relicensure requirements for laboratory personnel. Participants should claim only the credit commensurate with the extent of their participation in the activity. 

Note: Members of AMP can access this webinar at no cost. Join the AMP Family!

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