Horizons Series: TPMT and NUDT15 Genotyping Recommendations
TPMT and NUDT15 Genotyping Recommendations: A Joint ConsensusThis contains the webinar and continuing education credit (CME and CMLE)
In this pre-recorded lecture,
AMP Pharmacogenomics Working Group members Dr. Reynold Ly moderates as Dr.
Makenzie Fulmer provides an update on clinical TPMT and NUDT15 testing, which
was recently published online by the JMD. With a goal of promoting standardization
of clinical PGx testing across different clinical laboratories, this Working
Group has published recommendations on CYP2C19, CYP2C9, Warfarin allele and
CYP2D6 genotyping allele selections previously, and now TPMT and NUDT15
selection for clinical laboratories to use as guidelines when designing and
developing these PGx assays. Healthcare providers may also find these documents
useful in comparing and contrasting PGx tests across clinical laboratories when
they are familiar with a “must-test” list for each of the pharmacogenes.
- Review TPMT and NUDT15 pharmacogenetics (PGx) and highlight the importance of standardization of clinical PGx and its implications to patient care
- Review the AMP PGx Working Group ‘Tier’ system of PGx sequence variants/alleles recommendation
- Explain the key attributes of Tier 1 and Tier 2 recommended alleles for TPMT and NUDT15 genotyping
Makenzie L. Fulmer, PhD
Department of Pathology and ARUP Laboratories
Reynold C. Ly, PhD
University School of Medicine,
Duration: 1 Hour
Level of Instruction: Intermediate
Date Recorded: August 30, 2022
Planned and coordinated by the Training and Education Committee
Continuing Education Credit InformationCME credit: 1.0
CMLE credit: 1.0
Last day to claim credit: March 20, 2025
AMA PRA Category 1 Credit(s)™
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint providership of American Society for Clinical Pathology (ASCP) and Association for Molecular Pathology (AMP). The American Society for Clinical Pathology (ASCP) is accredited by the ACCME to provide continuing medical education for physicians.
The ASCP designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only credit commensurate with the extent of their participation in the activity.
This continuing medical laboratory education activity is recognized by the American Society for Clinical Pathology for 1.0 hours of CMLE credit. ASCP CMLE credit hours are acceptable for the ASCP Board of Certification (BOC) Certification Maintenance Program (CMP). CMLE credit hours meet the continuing education requirements for the ASCP Board of Certification Credential Maintenance Program (CMP) and state relicensure requirements for laboratory personnel. Participants should claim only the credit commensurate with the extent of their participation in the activity.
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