Mutational Signatures in cancer: Recent Findings, Laboratory Considerations, and Clinical Implications

Mutational Signatures in cancer

This webinar is a recorded presentation of a live broadcast and includes a pre-test, the presentation, , audience Q&A, handout, and a post-test. Continuing Education is available for the webinar.


Patterns of somatic mutation, identified through the broad sequencing of human cancers, reflect diverse mechanisms of tumorigenesis. These patterns, so-called mutational signatures, represent emerging biomarkers that provide insight into disease etiology and may impact clinical management. This webinar reviews the mechanistic basis of mutational signatures, the detection of signatures in the molecular laboratory, and potential implications in cancer diagnosis and treatment.

Learning Objectives:
  • Describe how mechanisms of mutagenesis lead to distinct mutational signatures.
  • Infer common mutational signatures from sequencing data.
  • Use mutational signatures to support pathological diagnosis and laboratory quality control.
  • Explain how mutational signatures may aid cancer therapy selection.


Fei Dong, MD


Kurtis Davies, MD

Duration: 1 Hour
Level of Instruction: Basic
Date Recorded: May 3, 2022

This webinar is part of the Emerging and Evolving Biomarkers Series

This program has been supported through educational grant funding provided by Amgen and Loxo Oncology at Lilly (for further information concerning Lilly grant funding visit Supporting companies had no control over its content. No personally-identifiable information regarding you is provided to any grant supporters.

How to Register:
  1. Click the "Enroll" Button
  2. Log in using your AMP credentials. If you do not have an AMP account, Create a FREE account.
  3. Complete the "Demographic questionnaire for Emerging and Evolving Biomarkers Series". You will only need to do this once for the entire series.

Continuing Education Credit Information

CME credit: 1.0
CMLE credit: 1.0 
Last day to claim credit: December 31, 2022

Accreditation Statements
AMA PRA Category 1 Credit(s)
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint providership of American Society for Clinical Pathology (ASCP) and Association for Molecular Pathology (AMP). The American Society for Clinical Pathology (ASCP) is accredited by the ACCME to provide continuing medical education for physicians.

The ASCP designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

This continuing medical laboratory education activity is recognized by the American Society for Clinical Pathology for 1.0 hours of CMLE credit. ASCP CMLE credit hours are acceptable for the ASCP Board of Certification (BOC) Certification Maintenance Program (CMP). CMLE credit hours meet the continuing education requirements for the ASCP Board of Certification Credential Maintenance Program (CMP) and state relicensure requirements for laboratory personnel. Participants should claim only the credit commensurate with the extent of their participation in the activity.

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