Mutational Signatures in cancer: Recent Findings, Laboratory Considerations, and Clinical Implications

Mutational Signatures in cancer

This webinar is a recorded presentation of a live broadcast and includes a pre-test, the presentation, , audience Q&A, handout, and a post-test. Continuing Education is available for the webinar. 

CME/CMLE Credit is not available for this webinar.


Patterns of somatic mutation, identified through the broad sequencing of human cancers, reflect diverse mechanisms of tumorigenesis. These patterns, so-called mutational signatures, represent emerging biomarkers that provide insight into disease etiology and may impact clinical management. This webinar reviews the mechanistic basis of mutational signatures, the detection of signatures in the molecular laboratory, and potential implications in cancer diagnosis and treatment.

Learning Objectives:
  • Describe how mechanisms of mutagenesis lead to distinct mutational signatures.
  • Infer common mutational signatures from sequencing data.
  • Use mutational signatures to support pathological diagnosis and laboratory quality control.
  • Explain how mutational signatures may aid cancer therapy selection.


Fei Dong, MD


Kurtis Davies, MD

Duration: 1 Hour
Level of Instruction: Basic
Date Recorded: May 3, 2022

This webinar is part of the Emerging and Evolving Biomarkers Series

This program has been supported through educational grant funding provided by Amgen and Loxo Oncology at Lilly (for further information concerning Lilly grant funding visit Supporting companies had no control over its content. No personally-identifiable information regarding you is provided to any grant supporters.

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  3. Complete the "Demographic questionnaire for Emerging and Evolving Biomarkers Series". You will only need to do this once for the entire series.

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