Emerging and Evolving Biomarkers: Methylation Profiling

Brent A. Orr MD, PhD


Anthony Snow, MD

CME/CMLE Credit is not available for this webinar.


DNA methylation plays an essential role in regulating gene transcription and cell fate. Both normal tissues and neoplasms have unique genome-wide methylation signatures that can be interrogated using modern molecular techniques. This presentation will describe the clinical applications of genome-wide DNA methylation profiling and its emerging role as a tumor biomarker. Emphasis will be placed on how DNA methylation profiling can refine tumor classification schemes and be utilized as a clinical diagnostic for molecular tumor classification.

Learning Objectives:

  • Describe the basic biology of DNA methylation and the specific technologies used to detect DNA methylation in the clinical environment.
  • Describe how tumor classification schemes can be refined using unsupervised methylation profiling.
  • Describe how methylation profiling can be used as a clinical diagnostic in the molecular pathology laboratory.

 Emerging and Evolving Biomarkers Series.

This program has been supported through educational grant funding provided by Amgen and Loxo Oncology at Lilly (for further information concerning Lilly grant funding visit www.lillygrantoffice.com.) Supporting companies had no control over its content. No personally-identifiable information regarding you is provided to any grant supporters.

Recording Date: January 25, 2022
Duration: 1 Hour
Level of Instruction: Basic

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