Emerging and Evolving Biomarkers: Methylation Profiling

Brent A. Orr MD, PhD


Anthony Snow, MD



DNA methylation plays an essential role in regulating gene transcription and cell fate. Both normal tissues and neoplasms have unique genome-wide methylation signatures that can be interrogated using modern molecular techniques. This presentation will describe the clinical applications of genome-wide DNA methylation profiling and its emerging role as a tumor biomarker. Emphasis will be placed on how DNA methylation profiling can refine tumor classification schemes and be utilized as a clinical diagnostic for molecular tumor classification.

Learning Objectives:

  • Describe the basic biology of DNA methylation and the specific technologies used to detect DNA methylation in the clinical environment.
  • Describe how tumor classification schemes can be refined using unsupervised methylation profiling.
  • Describe how methylation profiling can be used as a clinical diagnostic in the molecular pathology laboratory.

 Emerging and Evolving Biomarkers Series.

This program has been supported through educational grant funding provided by Amgen and Loxo Oncology at Lilly (for further information concerning Lilly grant funding visit www.lillygrantoffice.com.) Supporting companies had no control over its content. No personally-identifiable information regarding you is provided to any grant supporters.

Recording Date: January 25, 2022
Duration: 1 Hour
Level of Instruction: Basic
CME/CMLE Credit: 1.0 
Last day to claim credit: December 31, 2022

How to claim credit: 

To earn CME/CMLE credit, all learners must watch the webinar and then complete the online survey.

AMA PRA Category 1 Credit(s)™

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint providership of American Society for Clinical Pathology (ASCP) and Association for Molecular Pathology (AMP). The American Society for Clinical Pathology (ASCP) is accredited by the ACCME to provide continuing medical education for physicians.

The ASCP designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

This continuing medical laboratory education activity is recognized by the American Society for Clinical Pathology for 1.0 hours of CMLE credit. ASCP CMLE credit hours are acceptable for the ASCP Board of Certification (BOC) Certification Maintenance Program (CMP). CMLE credit hours meet the continuing education requirements for the ASCP Board of Certification Credential Maintenance Program (CMP) and state relicensure requirements for laboratory personnel. Participants should claim only the credit commensurate with the extent of their participation in the activity.

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