AMP Horizons Series: Recommendations for Clinical CYP2D6 Genotyping Allele Selection

CME and CMLE credits are not available for this course.

A Joint Consensus Recommendation of the Association for Molecular Pathology, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, and European Society for Pharmacogenomics and Personalized Therapy


AMP Pharmacogenomics Working Group members Dr. Andria del Tredici moderates as Dr. Ann Moyer provides an update on clinical CYP2D6 testing, which was recently published online by the JMD. With a goal of promoting standardization of clinical PGx testing across different clinical laboratories, this Working Group has published recommendations on CYP2C19, CYP2C9 and Warfarin allele selections previously, and now the CYP2D6 genotyping allele selection for clinical laboratories to use as guidelines when designing and developing these PGx assays. Healthcare providers may also find these documents useful in comparing and contrasting PGx tests across clinical laboratories when they are familiar with a “must-test” list for each of the pharmacogenes.

Learning Objectives:

  • Review CYP2D6 pharmacogenetics (PGx) and highlight the importance of standardization of clinical PGx and its implications to patient care
  • Review the AMP PGx Working Group ‘Tier’ system of PGx sequence variants/alleles recommendation
  • Explain the key attributes of Tier 1 and Tier 2 recommended alleles for CYP2D6 genotyping

Practice Guideline Available Here

Picture of Speaker Ann Moyer
 Picture of Moderator, Andria del Tredici
Ann Moyer, MD, PhD
Mayo Clinic
Rochester, MN
Andria del Tredici, PhD
Acadia Pharmaceuticals
San Diego, CA

 1 hr
Level of Instruction: Basic
Date Recorded: June 15, 2021

Continuing Education Credit Information

CME and CMLE credits are not available for this course.

Note: Members of AMP can access this webinar at no cost. Join the AMP Family!

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