Emerging and Evolving Biomarkers: METex14

 This content was created in 2020, but has been reviewed and approved by the Training & Education Committee as useful, accurate, and relevant. Please note that in the time since this material was posted, there may have been additional developments, advancements, and/or more current publications in this field.

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This webinar does not contain continuing education credit (CME and CMLE) 

Speaker: Nikoletta Sidiropoulos, MD	Moderator: Anthony Snow, MD

This webinar is a recorded presentation of a live broadcast and includes the presentation, handout, and the audience QA.

Description:

The mesenchymal epithelial transition factor (MET) gene encodes a receptor tyrosine kinase. MET juxtamembrane (JM) splicing variants or exon 14 skipping variants result in loss of exon 14 containing the JM domain of MET. As this domain is a negative regulator of MET the net result is oncogenic. Targeted therapies have been shown to be effective therapeutic options in some clinical settings when this variant type is present. Data is well developed in non-small cell carcinomas of the lung and ongoing trials in other solid tumors are underway as these variants are variably present in multiple tumor types at frequencies of approximately 1-4%. The scientific background information, testing techniques, and clinical applications of this biomarker will be discussed.

Learning Objectives:

• Describe the underlying molecular biology of METex14 mutations.
• Review technical approaches for the detection of METex14 mutations.
• Discuss the clinical relevance of METex14 mutations.

Recording Date: September 29, 2020
Duration: 1 hr
Level of Instruction: Basic

This webinar does not contain continuing education credit (CME and CMLE) 

This webinar is part 3 of the Emerging and Evolving Biomarkers Series. 

This program has been supported through an educational grant from Bristol-Myers Squibb.

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