Emerging and Evolving Biomarkers: HRD Score





This content was created in 2020, but has been reviewed and approved by the Training & Education Committee as useful, accurate, and relevant. Please note that in the time since this material was posted, there may have been additional developments, advancements, and/or more current publications in this field.


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This webinar does not contain continuing education credit (CME and CMLE) 


Melinda Telli, MD


Kurtis Davies, PhD

This webinar is a recorded presentation of a live broadcast and includes the presentation, handout, and the audience QA.



Homologous recombination deficiency score (HRD) includes assessment of loss of heterozygosity, large-scale state transitions, and telomeric allelic imbalance as an assessment of functional loss of homologous recombination repair. HRD score has been studied in multiple tumor types with the aim of predicting therapeutic response independent of homologous recombination repair gene mutation status. The scientific background, testing considerations, and clinical implications will be discussed in this presentation.

Learning Objectives: 

1. Describe the biological principles that underlie the relevance of HRD score, including the cellular signaling pathways and cellular processes involved.

2. Discuss the appropriate technical approaches and platforms for HRD score molecular diagnostic testing.

3. Outline the strengths and limitations of described testing approaches.

4. Apply HRD score information so as to order appropriate testing and interpret test results within a clinical context.

This webinar is part 2 of the Emerging and Evolving Biomarkers Series

This program has been supported through an educational grant from Bristol-Myers Squibb.

Recorded Date: July 21, 2020
Duration: 1 hr
Level of Instruction: Basic
This webinar does not contain continuing education credit (CME and CMLE) 




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