Recommendations for Clinical Warfarin Sensitivity Genotyping Allele Selection: A Joint Report of AMP and CAP


This is an update from the AMP Pharmacogenomics Working Group on clinical warfarin sensitivity testing, which was recently published on line by the JMD. With a goal of promoting standardization of clinical PGx testing across different clinical laboratories, this Working Group has published recommendations on CYP2C19 and CYP2C9 allele selections previously, and now the Warfarin sensitivity genotyping allele selection for clinical laboratories to use as guidelines when designing and developing these PGx assays. Healthcare providers may also find these document useful in comparing and contrasting PGx tests across clinical laboratories when they are familiar with a “must-test” list for each of the pharmacogenes.

Learning Objectives:

  • Review Warfarin pharmacogenetics (PGx) and highlight the importance of standardization of clinical PGx and its implications to patient care.
  • Review the AMP PGx Working Group 'Tier' system of PGx sequence variants/alleles recommendation.
  • Explain the key attributes of Tier 1 and Tier 2 recommended alleles for clinical Warfarin sensitivity genotyping.

Practice Guideline Available Here

Yuan Ji, PhD, FACMG
Andria L. Del Tredici, PhD

 1 hr
Level of Instruction: Basic
Recorded: March 10, 2020

Continuing Education Credit Information

CME credit: 1.0
CMLE credit: 1.0
Last day to purchase course and claim credit: March 20, 2022

Accreditation Statements
AMA PRA Category 1 Credit(s)™
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint providership of American Society for Clinical Pathology (ASCP) and Association for Molecular Pathology (AMP). The American Society for Clinical Pathology (ASCP) is accredited by the ACCME to provide continuing medical education for physicians.

The ASCP designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

This continuing medical laboratory education activity is recognized by the American Society for Clinical Pathology for 1.0 hours of CMLE credit. ASCP CMLE credit hours are acceptable for the ASCP Board of Certification (BOC) Certification Maintenance Program (CMP). CMLE credit hours meet the continuing education requirements for the ASCP Board of Certification Credential Maintenance Program (CMP) and state relicensure requirements for laboratory personnel. Participants should claim only the credit commensurate with the extent of their participation in the activity. 

Note: Members of AMP can access this webinar at no cost. Join the AMP Family!

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