Emerging and Evolving Biomarkers: MGMT
Tejus A. Bale, MD, PhD
Lauren Ritterhouse, MD, PhD
This webinar is a recorded presentation of a live broadcast and includes the presentation, handout, and the audience QA.
The O6-methylguanine-DNA methyl-transferase (MGMT) gene encodes a widely expressed DNA repair enzyme, which reverses the anti-tumor effects of alkylating agents. Silencing of the MGMT gene, via promoter methylation, has emerged as a biomarker of interest in glioma with regards to tumor prognostication and treatment selection. In the era of numerous biologically relevant glioma biomarkers, the relative significance of MGMT testing will be considered, as well as the technical considerations and constraints surrounding commonly utilized assays.
- Describe the function of O6-methylguanine-DNA methyl-transferase (MGMT) and the effects of gene promoter methylation.
- Describe the clinical significance of MGMT promoter methylation with regards to glioma therapy and risk stratification.
- Discuss the commonly used technical approaches and platforms for molecular diagnostic testing for MGMT gene methylation.
- Outline the strengths and limitations of described testing approaches.
This webinar is part 1 of the Emerging and Evolving Biomarkers Series.
Recording Date: June 30, 2020
Duration: 1 hr
Level of Instruction: Basic
CME/CMLE credit: 1.00 hour
Last Day to Claim CE Credit: December 31, 2022
How to claim credit:
To earn CME/CMLE credit, all learners must watch the webinar and then complete the online survey.
AMA PRA Category 1 Credit(s)™
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