Emerging and Evolving Biomarkers: MGMT


Tejus A. Bale, MD, PhD


Lauren Ritterhouse, MD, PhD

This webinar is a recorded presentation of a live broadcast and includes the presentation, handout, and the audience QA.


The O6-methylguanine-DNA methyl-transferase (MGMT) gene encodes a widely expressed DNA repair enzyme, which reverses the anti-tumor effects of alkylating agents. Silencing of the MGMT gene, via promoter methylation, has emerged as a biomarker of interest in glioma with regards to tumor prognostication and treatment selection. In the era of numerous biologically relevant glioma biomarkers, the relative significance of MGMT testing will be considered, as well as the technical considerations and constraints surrounding commonly utilized assays.

Learning Objectives:

  • Describe the function of O6-methylguanine-DNA methyl-transferase (MGMT) and the effects of gene promoter methylation.
  • Describe the clinical significance of MGMT promoter methylation with regards to glioma therapy and risk stratification. 
  • Discuss the commonly used technical approaches and platforms for molecular diagnostic testing for MGMT gene methylation. 
  • Outline the strengths and limitations of described testing approaches.

This webinar is part 1 of the Emerging and Evolving Biomarkers Series

This program has been supported through an educational grant from Bristol-Myers Squibb.

Recording Date: June 30, 2020
Duration: 1 hr
Level of Instruction: Basic
CME/CMLE credit: 1.00 hour

Last Day to Claim CE Credit: December 31, 2022

How to claim credit: 

To earn CME/CMLE credit, all learners must watch the webinar and then complete the online survey.

AMA PRA Category 1 Credit(s)™

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint providership of American Society for Clinical Pathology (ASCP) and Association for Molecular Pathology (AMP). The American Society for Clinical Pathology (ASCP) is accredited by the ACCME to provide continuing medical education for physicians.

The ASCP designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

This continuing medical laboratory education activity is recognized by the American Society for Clinical Pathology for 1.0 hours of CMLE credit. ASCP CMLE credit hours are acceptable for the ASCP Board of Certification (BOC) Certification Maintenance Program (CMP). CMLE credit hours meet the continuing education requirements for the ASCP Board of Certification Credential Maintenance Program (CMP) and state relicensure requirements for laboratory personnel. Participants should claim only the credit commensurate with the extent of their participation in the activity.

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