Emerging and Evolving Biomarkers: MGMT




This content was created in 2020, but has been reviewed and approved by the Training & Education Committee as useful, accurate, and relevant. Please note that in the time since this material was posted, there may have been additional developments, advancements, and/or more current publications in this field.


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This webinar does not contain continuing education credit (CME and CMLE) 


Tejus A. Bale, MD, PhD


Lauren Ritterhouse, MD, PhD

This webinar is a recorded presentation of a live broadcast and includes the presentation, handout, and the audience QA.



The O6-methylguanine-DNA methyl-transferase (MGMT) gene encodes a widely expressed DNA repair enzyme, which reverses the anti-tumor effects of alkylating agents. Silencing of the MGMT gene, via promoter methylation, has emerged as a biomarker of interest in glioma with regards to tumor prognostication and treatment selection. In the era of numerous biologically relevant glioma biomarkers, the relative significance of MGMT testing will be considered, as well as the technical considerations and constraints surrounding commonly utilized assays.

Learning Objectives:

  • Describe the function of O6-methylguanine-DNA methyl-transferase (MGMT) and the effects of gene promoter methylation.
  • Describe the clinical significance of MGMT promoter methylation with regards to glioma therapy and risk stratification. 
  • Discuss the commonly used technical approaches and platforms for molecular diagnostic testing for MGMT gene methylation. 
  • Outline the strengths and limitations of described testing approaches.

This webinar is part 1 of the Emerging and Evolving Biomarkers Series

This program has been supported through an educational grant from Bristol-Myers Squibb.

Recording Date: June 30, 2020
Duration: 1 hr
Level of Instruction: Basic
This webinar does not contain continuing education credit (CME and CMLE)




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