AMP/ASCO/CAP Standards and Guidelines of Somatic Variant Interpretation and Reporting

This content was created in 2018, but has been reviewed and approved by the Training & Education Committee as useful, accurate, and relevant. Please note that in the time since this material was posted, there may have been additional developments, advancements, and/or more current publications in this field.

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In January 2017, a working group comprised of representatives from the Association for Molecular Pathology (AMP), College of American Pathologists (CAP), American Society of Clinical Oncology (ASCO), and American College of Medical Genetics and Genomics (ACMG) published the guidelines for the interpretation and reporting of somatic variants. This subject matter expert panel comprised of investigators with expertise in molecular pathology, medical genetics, and clinical oncology, assessed the current status of NGS-based testing for cancer and established standardized classification, annotation, interpretation, and reporting conventions for sequence variants associated with cancer.

In this webinar, Dr. Marilyn M. Li summarizes the guideline and provides a number of examples illustrating how to implement the classification system.

Learning Objectives:

  • Evaluate current status of interpretation and reporting of sequence variants in cancer and recognize the urgent needs of standardization.
  • Discuss different levels of evidence used for variant classification.
  • Describe the tier-based variant classification centered on clinical and experimental evidence.
  • Identify the tier-based reporting system, the nomenclature of sequence variants and essential components of reports for cancer sequencing tests.

Practice Guideline Available Here

Speaker: Marilyn M. Li, MD
Host: Antonia R. Sepulveda, MD, PhD
Duration: 1 hr
Level of Instruction: Basic
Date Recorded: January 26, 2018

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