Practical Considerations for the Validation of Next-Generation Sequencing-Based Oncology Panels

Description: 

Validation of NGS-based testing for oncology panels can be challenging given the many steps and wide range of targeted mutations. In this presentation, Dr. Jennings will discuss the recent AMP/CAP guideline recommendations for validation and review practical ways to provide documented evidence with the clinical NGS reports.

Learning Objectives:

  • Describe an error-based approach to validation and choose which sources of variation need to be assessed.
  • Estimate the number of samples that are needed to confidently achieve a stated reliability.
  • Use tolerance limits to define minimum QC performance criteria.
  • Compare ways to assess library complexity.

Practice Guideline Available Here

Speaker: Lawrence J. Jennings, MD, PhD
Moderator: Antonia R. Sepulveda, MD, PhD
Duration: 1 hr
Level of Instruction: Basic
Date Recorded: April 25, 2018

Continuing Education Credit Information

CME credit: 1.0
CMLE credit: 1.0
 
SAM credit : 1.0
Last day to purchase course and claim credit: March 20, 2021
* You may not submit SAMs and CME/CMLE credit for the same content.

Accreditation Statements
AMA PRA Category 1 Credit(s)™
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint providership of American Society for Clinical Pathology (ASCP) and Association for Molecular Pathology (AMP). The American Society for Clinical Pathology (ASCP) is accredited by the ACCME to provide continuing medical education for physicians.

The ASCP designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

CMLE
This continuing medical laboratory education activity is recognized by the American Society for Clinical Pathology for 1.0 hours of CMLE credit. ASCP CMLE credit hours are acceptable for the ASCP Board of Certification (BOC) Certification Maintenance Program (CMP). CMLE credit hours meet the continuing education requirements for the ASCP Board of Certification Credential Maintenance Program (CMP) and state relicensure requirements for laboratory personnel. Participants should claim only the credit commensurate with the extent of their participation in the activity. 

SAM
This course is approved by the American Board of Pathology for 1.0 SAM credits. Physicians should only claim credit commensurate with the extent of their participation in the activity. Participants must successfully complete the online modular exams (answering at least 80% of the questions in a topic module correctly).


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