Tumor Mutational Burden: Best Practices to Address Clinical and Technical Challenges


Jonathan Nowak, M.D.,Ph.D.


Jeremy Segal, MD, PhD

This webinar is a recorded presentation of a live broadcast and includes the presentation, handout, and the audience QA.


This webinar will cover the methodology for calculating tumor mutational burden (TMB) and will review technical considerations that can impact TMB calculation. The utility of detecting the underlying mutational processes that determine a tumor's mutational burden will also be discussed. The course will cover an overview of immunotherapy drugs, targets, and tumor types for which TMB has been used as a biomarker.

Learning Objectives:

  • Describe laboratory and bioinformatic factors that can influence TMB calculation.
  • Describe the underlying mutational processes that give rise to a tumor's mutational burden

Recording Date: August 28, 2018
Duration: 1 hr
Level of Instruction: Basic

CE Credit for this course has expired.

This webinar is part 2 of a three-part series exploring how measuring tumor mutational burden can improve patient care.

For more information on this series, please go here.

This program has been supported through an educational grant from Bristol-Myers Squibb.

Note: Members of AMP can access many of the webinars at no cost or a deep discount. Join the AMP Family!

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