Tumor Mutational Burden: Best Practices to Address Clinical and Technical Challenges


Jonathan Nowak, M.D.,Ph.D.


Jeremy Segal, MD, PhD

This webinar is a recorded presentation of a live broadcast and includes the presentation, handout, and the audience QA.

Please note that this content was created in 2018. In the time since this material was posted, there may have been additional developments, advancements, and/or more current publications in this field.

AMP Education is constantly updating our educational offerings, and will remove or replace content that is no longer accurate. Please be sure to use the search function to find related or updated material available in our catalogue at educate.amp.org. The Training and Education Committee works with AMP Education Programs to bring you the most up-to-date and cutting-edge information on molecular pathology research, applications, and training.


This webinar will cover the methodology for calculating tumor mutational burden (TMB) and will review technical considerations that can impact TMB calculation. The utility of detecting the underlying mutational processes that determine a tumor's mutational burden will also be discussed. The course will cover an overview of immunotherapy drugs, targets, and tumor types for which TMB has been used as a biomarker.

Learning Objectives:

  • Describe laboratory and bioinformatic factors that can influence TMB calculation.
  • Describe the underlying mutational processes that give rise to a tumor's mutational burden

Recording Date: August 28, 2018
Duration: 1 hr
Level of Instruction: Basic

CE Credit for this course has expired.

This webinar is part 2 of a three-part series exploring how measuring tumor mutational burden can improve patient care.

For more information on this series, please go here.

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