Tumor Mutational Burden: Best Practices to Address Clinical and Technical Challenges
Jonathan Nowak, M.D.,Ph.D.
Jeremy Segal, MD, PhD
This webinar is a recorded presentation of a live broadcast and includes the presentation, handout, and the audience QA.
This webinar will cover the methodology for calculating tumor mutational burden (TMB) and will review technical considerations that can impact TMB calculation. The utility of detecting the underlying mutational processes that determine a tumor's mutational burden will also be discussed. The course will cover an overview of immunotherapy drugs, targets, and tumor types for which TMB has been used as a biomarker.
- Describe laboratory and bioinformatic factors that can influence TMB calculation.
- Describe the underlying mutational processes that give rise to a tumor's mutational burden
Recording Date: August 28, 2018
Duration: 1 hr
Level of Instruction: Basic
CME/CMLE credit: 1.00 hour
SAM credit: 1.00 hour
Last Day to Purchase Credit: December 31, 2020
How to claim credit:
To earn CME/CMLE credit, all learners must watch the webinar and then complete the online survey.
AMA PRA Category 1 Credit(s)™
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint providership of American Society for Clinical Pathology (ASCP) and Association for Molecular Pathology (AMP). The American Society for Clinical Pathology (ASCP) is accredited by the ACCME to provide continuing medical education for physicians.
The ASCP designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only credit commensurate with the extent of their participation in the activity.
This continuing medical laboratory education activity is recognized by the American Society for Clinical Pathology for 1.0 hours of CMLE credit. ASCP CMLE credit hours are acceptable for the ASCP Board of Certification (BOC) Certification Maintenance Program (CMP). CMLE credit hours meet the continuing education requirements for the ASCP Board of Certification Credential Maintenance Program (CMP) and state relicensure requirements for laboratory personnel. Participants should claim only the credit commensurate with the extent of their participation in the activity.
To earn SAM credit, all learners must watch the webinar, achieve a minimum score of 80% on the online quiz, and complete an online survey.
This course is approved by the American Board of Pathology for 1.0 SAM credits.Physicians should only claim credit commensurate with the extent of their participation in the activity. Participants must successfully complete the online modular exams (answering at least 80% of the questions in a topic module correctly).* You may not submit SAMs and CME/CMLE credit for the same content.This webinar is part 2 of a three-part series exploring how measuring tumor mutational burden can improve patient care.
For more information on this series, please go here.
This program has been supported through an educational grant from Bristol-Myers Squibb.
Note: Members of AMP can access many of the webinars at no cost or a deep discount. Join the AMP Family!
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