This collection will give you access to the recordings of the presentations (listed below) and pdf slides only. CME/CMLE or SAM is not available for this collection


Description:

Did you miss out on joining us in Charlotte for the AMP 2016 Annual Meeting? Were you there but missed something you really wanted to see? We have you covered with the AMP 2016 Annual Meeting Highlights. Select presentations were recorded and are now available for online viewing.

 

Presentations and Speakers :

The AMP Award for Excellence in Molecular Diagnostics Lecture: Discovering the Genetic Basis of Human Disease: The 35-Year Journey of Genomic Medicine (1.25)

  • Eric Lander, PhD

 

It’s a Big Data World: Leveraging Available Genomic and Clinical Data to Advance Diagnostics

  • Atul Butte, MD, PhD

  • Christopher G. Chute, MD

 

A View from Across the Pond: European Models for Molecular Infectious Disease Testing

  • Mark Wilcox, MD

  • Kate Cuschieri, PhD

 

Liquid Biopsies and Analysis of Cell-Free DNA in Cancer Patients

  • Michael R. Speicher, MD

  • Maximillian Diehn, MD, PhD

 

CHIPping Away at the Mysteries of Hematopoeiesis: The Science and Clinical Implications of CHIP

  • Benjamin Ebert, MD, PhD

  • David P. Steensma, MD

 

Design, Validation, and Implementation of Effective Quality Control Materials for NGS/NIPS in a Clinical Laboratory

  • Lisa V. Kalman, PhD

  • Glenn E. Palomaki, PhD

 


Duration: 8.25 hrs

 

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Course Information
Course Date:
November 10, 2016
Click on a topic name to see details and purchase options.
Thursday November 10, 2016
Not Available for Individual Purchase

The talk will discuss the foundations for discovering the genetic basis of common human diseases—including the early development of theoretical methods for mapping the genes underlying polygenic traits; sequencing of the human genome comprehensive discovery of the genetic variation in the human population; systematic characterization of genomic features; and empirical insights into the genetic architecture of common human disease. It will then describe recent progress in genetic analysis of important diseases—such as schizophrenia, heart disease, inflammatory bowel disease and obesity—and close by looking forward to the years ahead.

  • Recognize the history of discovering the genetic basis of human diseases.
  • Analyze the characterization of genetic variation and genomic features.
  • Conclude that progress in genomic medicine will be based on emerging discoveries.

Speaker: Eric S. Lander, PhD, Broad Institute of Harvard and MIT, Cambridge, MA, USA

Duration: 1.25 hr

Recording Date: November 10, 2016

 

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Lander Presentation
AMP Regular Member: $49.50
AMP Technologist Member: $49.50
AMP Associate Member: $49.50
Non-member Price: $97.50

This session presents how growing amounts of public data can be to leveraged to support and advance the development of diagnostics.

  • Describe the potential value of individual patient laboratory data to biomedical research and public health.
  • Identify two significant challenges to the use of this data in the present-day research enterprise.
  • Explain the likely costs and benefits of this type of data reuse to your patients and your laboratory.

 

Translating a Trillion Points of Data into Therapies, Diagnostics, and New Insights into Disease

Atul Butte, MD, PhD, University of California, San Francisco, San Francisco, CA, USA

 

Clinical Informatics

Christopher G. Chute, MD, DrPH, Johns Hopkins University, Baltimore, MD, USA

 

Duration: 1.5 hr

Recording Date: November 10, 2016

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Butte and Chute Presentation
AMP Regular Member: $49.50
AMP Technologist Member: $49.50
AMP Associate Member: $49.50
Non-member Price: $97.50

Speakers will highlight the differences and challenges of European molecular diagnostic approaches compared to those in the U.S. with respect to Clostridium difficile-associated disease and for high-risk HPV detection in cervical cancer screening.

  • Outline differences between European diagnostic models compared to the US.
  • Describe available tests that have been incorporated into European testing paradigms.
  • Identify differences in patient outcomes observed using these different diagnostic practices

Testing Models for Clostridium difficile Infection Used in the UK

Mark Wilcox, MD, FRCPath, Leeds Teaching Hospital & University of Leeds, Leeds, West Yorkshire, UK

HPV Primary Screening: Challenges of Application and Implementation - and Priorities for Research

Kate Cuschieri, BSc, PhD, NHS Lothian, Edinburgh, United Kingdom

 

Duration: 1.5 hr

Recording Date: November 10, 2016

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Streaming
AMP Regular Member: $49.50
AMP Technologist Member: $49.50
AMP Associate Member: $49.50
Non-member Price: $97.50

The session explores the clinical applications of cell-free DNA and liquid biopsies in cancer patients.

  • Describe advances in technology that permit analysis of circulating biomarkers.
  • Explain the application of these technologies to diagnosis and treatment of cancer patients.
  • Discuss current issues and limitations regarding the utilization of these biomarkers.

Liquid Biopsy

Michael R. Speicher, MD, Medical University of Graz, Graz, Austria

ctDNA Analysis

Maximillian Diehn, MD, PhD, Stanford University, Stanford, CA, USA

 

Duration: 1.5 hr

Recording Date: November 10, 2016

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Speicher and Diehn Presentations
AMP Regular Member: $49.50
AMP Technologist Member: $49.50
AMP Associate Member: $49.50
Non-member Price: $97.50

The concept of “pre-cancer” clonal proliferation is fundamental to our understanding of the natural evolution of a variety of cancer types and an active area of research. Recent recognition of “pre-malignant” clonal hematopoiesis has been yet another exciting discovery in this area. The speakers will discuss their work in identifying Clonal Hematopoiesis of Indeterminate Potential (CHIP) and its relationship to both aging and the subsequent development of recognized hematopoietic malignancies.

  • Explain the concept of clonal hematopoiesis.
  • Describe how clonal hematopoiesis can be evaluated using markers identified by high-through sequencing.
  • Summarize current knowledge regarding the association between clonal hematopoiesis and the development of recognized hematopoietic cancers, particularly myelodysplastic syndromes.

 

Clonal Hematopoiesis of Indeterminate Potential

Benjamin Ebert, MD, PhD, Brigham and Women’s Hospital

CHIP, ICUS, MDS: A Clinical Perspective

David P. Steensma, MD, Dana-Farber Cancer Institute, Boston, MA, USA

 

Duration: 1.5 hr

Recording Date: November 10, 2016

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Ebert and Steensma Presentation
AMP Regular Member: $49.50
AMP Technologist Member: $49.50
AMP Associate Member: $49.50
Non-member Price: $97.50

As tests for large numbers of rare genetic conditions come on-line in clinical laboratories, it is becoming increasing difficult to obtain high-quality, well-characterized human samples to use for the purposes of test development, validation, and ongoing proficiency testing. The first presentation will review how the CDC GeT-RM program is helping laboratories access samples for these purposes. Non-invasive prenatal screening (NIPS) for the common triploidies, Down (T21), Edward (T18) and Patau (T13) syndromes, as well as numerical abnormalities of the sex chromosomes, is now firmly established as an extremely valuable screening tool. However, there is currently no universally accepted or adopted proficiency test (PT) for NIPS. The second presentation will review the substantial challenges in developing PT for NIPS, and review progress in its development.

  • Identify the sample resources available to laboratories through the Get-RM program.
  • Explain the challenges and current progress toward developing PT samples for NIPS testing.

 

Development of Reference Materials for Proficiency Testing and Quality Assurance

Lisa V. Kalman, PhD, Centers for Disease Control and Prevention, Atlanta, GA, USA

External Proficiency Assessment of Prenatal Cell Free (cf )DNA Testing for Aneuploidy

Glenn E. Palomaki, PhD, Women & Infants Hospital, Providence, RI, USA

Duration: 1.5 hr

Recording Date: November 10, 2016

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Kalman and Palomaki Presentation
AMP Regular Member: $49.50
AMP Technologist Member: $49.50
AMP Associate Member: $49.50
Non-member Price: $97.50
Individual topic purchase: Selected
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AMP 2016 Highlights
AMP Regular Member: $225.00
AMP Technologist Member: $225.00
AMP Associate Member: $225.00
Non-member Price: $325.00