Looking to add Next-Generation Sequencing (NGS) to your lab? Familiar with NGS but in need of a refresher? This 5-part series on the fundamentals of NGS is for you! Recorded in 2014 and 2015 “NGS 101” is a comprehensive primer on implementing and running NGS in your lab. To see details on the individual parts of this series, click “Topics.”

Course Information
Course Date:
December 31, 2015
NGS 101: NGS for the Clinic

This webinar provides a basic overview on facets of clinical NGS ranging from choosing and designing test contents to NGS sample preparation, sequencing technologies and post-analytic bioinformatic data analysis. Limitations of NGS technologies and how to work around them will also be discussed. Finally, practical guidance on important considerations prior to implementing NGS for clinical applications will be presented.

Speaker Information
Birgit Funke PhD, FACMG  [ view bio ]
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NGS101-01
AMP Regular Member: $0.00
AMP Technologist Member: $0.00
AMP Associate Member: $0.00
Non-member Price: $195.00
NGS 101: Viewing and Interpreting Sequencing Data

NGS sequencing, depending on the design and size of the analyzed genomic region, yields between tens to thousands of DNA variants. Handling of sequencing variants involves visualization of sequencing reads (alignments), identification of sequencing artifacts, filtering and prioritization of variants, interpretation and assignment of pathogenicity to variants, and finally correlation of variants with clinical presentation of the patient's disease. This webinar will provide an overview of useful tools, web-based data sets (e.g., 1,000 Genomes Project, NHLBI ESP database, HGVS LSDBs), predictor tools for splicing a functional protein, and genetic disease databases (e.g., HGMD, OMIM, PubMed) used for viewing and interpreting NGS sequencing data.

Speaker Information
Patrik Vitazka MD, PhD
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NGS101-02
AMP Regular Member: $0.00
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AMP Associate Member: $0.00
Non-member Price: $195.00
NGS 101: Validation and Implementation of Clinical Next-Generation Sequencing Based Tests for Inherited Disorders

Next-generation sequencing technologies are widely being adopted by laboratories for the diagnosis of inherited genetic disorders and in oncology. Although diagnostic laboratories are incorporating novel instruments and bioinformatics tools, laboratory directors are facing increasingly complex challenges in choosing appropriate approaches for assay selection and in developing comprehensive validation methods that examine the pre-analytical, analytical and post analytical phases of an assay. This webinar will present general considerations for approaches used for assay selection and validation of next-generation sequencing based tests for inherited genetic disorders.

Speaker Information
Avni Santani PhD  [ view bio ]
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NGS101-03
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AMP Associate Member: $0.00
Non-member Price: $195.00
NGS 101: Nomenclature in the Context of NGS Bioinformatics

In this webinar we will explore the bio-informatics workflow as it relates to generating a final list of annotated variants. Most data processing steps occur inside a black box, yet variant identification and annotation depend upon the tools utilized during the data processing steps. We will review these basic steps, identify limitations and challenges and review basic nomenclature standards.

Speaker Information
Robert Daber PhD  [ view bio ]
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NGS101-04
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AMP Associate Member: $0.00
Non-member Price: $195.00
NGS 101: The Role of the Pathologist in Reporting & Communicating Accurate and Succinct Results in the Genomic Era

Next-generation DNA sequencing technology is transforming clinical genetics, including for diagnosis of hereditary genetic conditions, and in tumor-based testing for precision cancer therapy. This new testing approach presents considerable challenges for pathology reporting. This presentation will review considerations related to pathologist reporting of next-generation sequencing results with a focus on germline cancer risk panels, tumor mutation hotspot panels, and comprehensive tumor sequencing panels.

Speaker Information
Colin C. Pritchard MD, PhD  [ view bio ]
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NGS101-05
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AMP Associate Member: $0.00
Non-member Price: $195.00
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