This product includes the webinar and SAM credit.


In this webinar, Dr. Karen Weck will present the recommendations of The AMP Pharmacogenomics Working Group of the Clinical Practice Committee for inclusion of variants in CYP2C19 genotyping panels. The working group has published consensus, evidence-based recommendations using criteria such as allele function, population frequency, and availability of reference materials. The recommendations include a Tier 1 minimum set of alleles and defining variants that should be included in all clinical CYP2C19 PGx tests, and a Tier 2 list of additional optional alleles that do not currently meet all of the criteria for inclusion in Tier 1. These recommendations are intended to aid clinical laboratory professionals when designing and validating CYP2C19 genotyping assays, promote standardization of testing across different laboratories, and complement existing clinical guidelines for pharmacogenetic testing.

Practice Guideline Available Here

Speaker: Karen E. Weck, MD

Host: Joshua Deignan, PhD

Duration: 1 hr

Level of Instruction: Basic

Last day to purchase course and claim credit: March 21, 2021

Maxiumum SAM credit available: 1.0

How to claim credit: To earn SAM credit, all learners must watch the webinar, achieve a minimum score of 80% on the online quiz, and complete an online survey. To access the quiz, click "Submit credit" on the course homepage or click on "My Credit" on the menu to the left and then "submit credit" for the appropriate course.

This course is approved by the American Board of Pathology for 1.0 SAM credits.Physicians should only claim credit commensurate with the extent of their participation in the activity. Participants must successfully complete the online modular exams (answering at least 80% of the questions in a topic module correctly).

* You may not submit SAMs and CME/CMLE credit for the same content.

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Course Information
Course Date:
March 21, 2018
Course Objectives
  • List the three most common alleles associated with CYP2C19 altered metabolism and their respective effects on enzymatic function.
  • Give examples of key drugs in clinical use that are affected by CYP2C19 genetic variability affecting enzymatic activity.
  • Describe the key characteristics of pharmacogenetic alleles that are recommended for inclusion in clinical testing platforms by the AMP PGx working group.
Recommendations for Clinical CYP2C19 Genotyping Allele Selection
Speaker Information
Karen E. Weck MD   [ view bio ]
Individual topic purchase: Selected
American Board of Pathology
Self-Assessment Module: 1.00
Weck Presentation (+SAM)
AMP Regular Member: $10.00
AMP Technologist Member: $10.00
AMP Associate Member: $10.00
Non-member Price: $215.00