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In January 2017, a working group comprised of representatives from the Association for Molecular Pathology (AMP), College of American Pathologists (CAP), American Society of Clinical Oncology (ASCO), and American College of Medical Genetics and Genomics (ACMG) published the guidelines for the interpretation and reporting of somatic variants. This subject matter expert panel comprised of investigators with expertise in molecular pathology, medical genetics, and clinical oncology, assessed the current status of NGS-based testing for cancer and established standardized classification, annotation, interpretation, and reporting conventions for sequence variants associated with cancer.

In this webinar, Dr. Marilyn M. Li summarizes the guideline and provides a number of examples illustrating how to implement the classification system.

Practice Guideline Available Here

Speaker: Marilyn M. Li, MD

Host: Antonia R. Sepulveda, MD, PhD

Duration: 1 hr

Level of Instruction: Basic


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SAM 1.0

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Continuing Education Credit must be purchased and claimed by January 26, 2021


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Course Information
Course Date:
January 26, 2018
Course Objectives
  • Evaluate current status of interpretation and reporting of sequence variants in cancer and recognize the urgent needs of standardization
  • Discuss different levels of evidence used for variant classification
  • Describe the tier-based variant classification centered on clinical and experimental evidence
  • Identify the tier-based reporting system, the nomenclature of sequence variants and essential components of reports for cancer sequencing tests
AMP/ASCO/CAP Standards and Guidelines of Somatic Variant Interpretation and Reporting
Speaker Information
Marilyn M. Li MD   [ view bio ]
Individual topic purchase: Selected
AMP Regular Member: $0.00
AMP Technologist Member: $0.00
AMP Associate Member: $0.00
Non-member Price: $195.00