This product includes the webinar and CME/CMLE credit.


In January 2017, a working group comprised of representatives from the Association for Molecular Pathology (AMP), College of American Pathologists (CAP), American Society of Clinical Oncology (ASCO), and American College of Medical Genetics and Genomics (ACMG) published the guidelines for the interpretation and reporting of somatic variants. This subject matter expert panel comprised of investigators with expertise in molecular pathology, medical genetics, and clinical oncology, assessed the current status of NGS-based testing for cancer and established standardized classification, annotation, interpretation, and reporting conventions for sequence variants associated with cancer.

In this webinar, Dr. Marilyn M. Li summarizes the guideline and provides a number of examples illustrating how to implement the classification system.


Practice Guideline Available Here

Speaker: Marilyn M. Li, MD

Host: Antonia R. Sepulveda, MD, PhD

Duration: 1 hr

Level of Instruction: Basic

Last day to purchase course and claim credit: January 26, 2021

Maximum CME/CMLE credit available: 1.0

How to claim credit: To earn CME/CMLE credit, all learners must watch the webinar and then complete the online survey. To access the online survey, click "Submit credit" on the course homepage, or click on "My Credit" on the menu to the left.

AMA PRA Category 1 Credit(s)™

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint providership of American Society for Clinical Pathology (ASCP) and Association for Molecular Pathology (AMP). The American Society for Clinical Pathology (ASCP) is accredited by the ACCME to provide continuing medical education for physicians.

The ASCP designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

This continuing medical laboratory education activity is recognized by the American Society for Clinical Pathology for 1.0 hours of CMLE credit. ASCP CMLE credit hours are acceptable for the ASCP Board of Certification (BOC) Certification Maintenance Program (CMP). CMLE credit hours meet the continuing education requirements for the ASCP Board of Certification Credential Maintenance Program (CMP) and state relicensure requirements for laboratory personnel. Participants should claim only the credit commensurate with the extent of their participation in the activity. 

* You may not submit SAMs and CME/CMLE credit for the same content.

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Course Information
Course Date:
January 26, 2018
Course Objectives
  • Evaluate current status of interpretation and reporting of sequence variants in cancer and recognize the urgent needs of standardization
  • Discuss different levels of evidence used for variant classification
  • Describe the tier-based variant classification centered on clinical and experimental evidence
  • Identify the tier-based reporting system, the nomenclature of sequence variants and essential components of reports for cancer sequencing tests
AMP/ASCO/CAP Standards and Guidelines of Somatic Variant Interpretation and Reporting
Speaker Information
Marilyn M. Li MD   [ view bio ]
Individual topic purchase: Selected
American Medical Association
Continuing Medical Education: 1.00
American Society for Clinical Pathology
CMLE: 1.00
Li Webinar +CME/CMLE
AMP Regular Member: $0.00
AMP Technologist Member: $0.00
AMP Associate Member: $0.00
Non-member Price: $205.00