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Following a brief overview on the difficulties encountered in the definition of the epidemiology, classification, diagnosis, prognosis, and therapy of peripheral T/NK-cell lymphomas, nodal peripheral T-cell lymphomas (PTCLs) will be discussed in detail. These neoplasms account for more than 60% of tumours stemming from peripheral T-lymphocytes. In the Revised WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, they correspond to 4 entities: PTCL, not otherwise specified (NOS), PTCLs related to follicular helper T-lymphocytes (FTH), ALK+ anaplastic large cell lymphoma (ALCL), and ALK- ALCL. Tumour related to TFH cells represent a new category, including angioimmunoblastic T-cell lymphoma (AITL), follicular T-cell lymphoma and neoplasms lacking the morphologic characteristics of the previous two subtypes but also stemming from TFH-elements. The latter group was in the past included among PTCLs/NOS. ALK- ALCL was promoted from provisional to accepted entity because of emerging molecular evidences. In addition, the new provisional category of breast implant-associated ALCL was included. Most of the changes introduced in the Revised WHO Classification by comparison with the 2008 fourth edition are due to the extensive application of molecular techniques, including gene expression profiling and next generation sequencing. All the changes will be highlighted and discussed.

A collaborative educational event presented by Association for Molecular Pathology (AMP) and Society for Hematopathology (SH).

Speaker: Stefano A. Pileri, MD

Host: Jennifer Dunlap, MD

Duration: 1 hr

Level of Instruction: Intermediate

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Course Information
Course Date:
January 18, 2018
Course Objectives
  • Discuss the complexity of the approach to peripheral T-cell lymphomas.
  • Explain the four categories of nodal peripheral T-cell lymphomas.
  • Identify potential targets for innovative therapies.
WHO 2016 Updates: Nodal Peripheral T-cell Lymphomas
Speaker Information
Stephano A. Pileri MD  [ view bio ]
Individual topic purchase: Selected
Pileri Presentation
AMP Regular Member: $0.00
AMP Technologist Member: $0.00
AMP Associate Member: $0.00
Non-member Price: $195.00